Background:
@EN the induced hypotension was used to decrease blood loss, thereby decreasing the need for blood transfusion and/or improving conditions at the surgical site. It was hypothesized that SNP-induced hypotension with fixed concomitant esmolol
infusion(75
㎍/kg min) might prevent side effects such as reflex tachycardia and reduce SNP dose requirement during SNP-induced hypotension.
@ES Method:
@EN The concomitant infusion of 75㎍/kg/min esmolol was used to potentiate hypotension(30% reduction of mean arterial blood pressure) induced with sodium nitroprusside in six dog during halthane(1vol%)-N2O(50%)-O2(50%) anesthesia. Mean arterial
blood
pressure, heart rate, cardiac output, mean pulmonary arterial blood pressure, central venous pressure, arterial blood gas analysis and mixed venous oxygen saturation were measured and systemic vascular resistance was calculated in the each
periods.
@ES Results:
@EN The results run as follows;
@EN 1) Compared to SNP-induced hypotension, there was significant reduction in SNP dose requirement to maintain a 30%reduction of mean arterial pressure at the concomitant infusion of 75㎍/kg/min esmolol. 2) There were significant reduction in
heart
rate, mixed venous oxygen saturation saturation and cardiac output, but significant increase in systemic vascular resistance and mean pulmonary arterial pressure at the concomitant infusion of 75㎍/kg/min esmolol. 3) No rebound hypertension was
observed
at 30 minute after SNP and esomolol infusion were simultaneously discontinued.
@ES Conclusion:
@EN The result of present study suggests that esmolol infusion is a safe and effective pharmacologic means of potentiating SNP-induced hypotension during halothane -N2O-O2 anesthesia. Probably esmolol may act by counteracting side effects such as
acute
tolerance during SNP-induced hypotension. (Korean J Anesthesiol 1996; 30: 649~657)
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